Cholesterol, Statins, and How They Function in the Body (Part 3)

How Statins Work

Statin drugs work by blocking a key enzyme in the production of cholesterol. Cholesterol is a natural product of the liver and in the right amounts does not pose a problem to the body. The body, however, sometimes produces too much cholesterol.(as mentioned due to toxin overload in the body) Statin drugs block the enzyme linked to the liver’s cholesterol production, HMG-CoA (3-hydroxy-3-methyglutaryl COA) reductase, thus inhibiting the liver’s ability to produce LDL. This causes an increase in the number of the LDL receptors on the surface of liver cells, resulting in more cholesterol being removed from the bloodstream and a reduction in risk for high-cholesterol related diseases.” (Little known fact is that toxins can negatively affect and oxidize HDL, “good” cholesterol just as much as LDL “bad” cholesterol) So if you are not addressing the root cause these drugs are especially not beneficial.

“There are two types of statin: fermentation-based and synthetic statins. The fermentation-based statins are derived from molds such as Aspergillus terreus.

Effect in the Body

The liver is primarily responsible for the production of cholesterol in the body. There are two main types of cholesterol: low-density lipoproteins (LDL) and high-density lipoproteins (HDL). LDL is the cholesterol referred to as the bad cholesterol. Statin drugs help to reduce the amount of LDL in the body. They do this by inhibiting the production of an enzyme in the liver that produces LDL–HMG-CoA reductase. They achieve this effect because statins are structurally similar to HMG-CoA reductase and effectively trick the body into thinking they are HMG-CoA, but actually disrupt the process of cholesterol formation. The liver, instead of producing more LDL, then begins to pull LDLs out of the body. By reducing the production of the enzyme, the production of LDL is reduced and overall cholesterol levels are brought down.”

Next, The Dangers of Low Cholesterol…..